PK-Works

Coming soon! Pre-order available!

Overview

PK-Works is applied pharmacokinetic (PK) software that has been developed to cater for a wide range of needs for scholars and clinical practitioners in the domain of PKs. It has emerged as full-fledged system addressing basic PK situations as well as those that has neither been adequately dealt with in the PK literature nor by any other similar application software. These include the PKs of intermittent infusion, missed doses, PK of sustained release dosage form (SRDFs), targeting of drugs plasma ranges and individualization of dosing regimen with particular emphasis on kidney failure and hepatic dysfunction.

Unlike any other software, PK-Works has been supplemented by an extensive PK database covering more than 1,450 drugs substances and 38,000 brand products that are in use in the Russian Federation, European Union, Japan, the United States and Canada.

The compilation of the PK metrics of generic drugs was based on information supplied by major drug information databases including the American Hospital Formulary Service, Martindale Extra Pharmacopeia, LexiComp, and the USP-DI.

Since the PK profiles for all generics is not always available, user are informed of such instances and are requested to use reliable PK metrics for further processing of their drugs of interest. Such limitation in system is strictly related to the availability of these metrics in the scientific literature and will be subject to continual resolution in the future editions of the system.

Interactive PK Modelling

1. Drug selection

User may select the drug of interest from PK-Works database that contains PK information for all drug molecules available in the USA and Canada (about 1,450 drugs). It also contains names of about 38,000 branded drug products. Clicking on the database button (marked with RED) will cause the display of the drug selection dialogue box marked with the GREEN border line.

2. Default Profile

Once user has selected the drug of interest, the system displays its oral single dose as a default profile.

3. A single dose IV bolus plasma profile

A single dose IV bolus plasma profile could be readily simulated if selected by the user.

4. Drug Selection Wizard

In some instances, information pertaining to the PK metrics for some drugs may not be complete. Hence, users are required to enter values for such parameters (marked with RED) as shown hereunder.

5. Simulation Parameters

User may alter any of the simulation parameters (e.g. t|0.5). The system will display the new profile caused by such alteration in RED. If user accepts the new output, simulation will proceed with the new profile.

6. Multiple Dosing

Multiple dosing: could be easily simulated by defining the number of administered doses.

7. Likely Plasma Levels

Likely plasma levels: if variability, expressed as StDev, associated with PK metrics for the elimination or absorption rate constants is provided by the user, the system will display the likely plasma levels.

8. Dose Loading

For drugs with relative long t|0.5, a loading dose may be estimated by the system. Such a dose will produce steady state (SS) plasma levels as shown.

Wiki

More information about the concept of PK-Works, scientific results and explanations, statistical data and presentations available at wiki area.

Videos

Screencasts of the product, coming soon.

Features

Precise drugs dosage calculation
Information based on top up-to-date 12 world-wide databases from 6 countries: The American Hospital Formulary Service (AHFS, USA), Hartman Ammon (Germany), The British National Formulary (BNF, GB), DataBank (dBank, Canada), Drugs.com (USA, New Zealand), Facts & Comparisons (F&C, USA), Philip Hansten (USA), Martindale (GB), Linfo (Sweden), The Rota Liste (Germany), Ivan Stockley (GB), USP-DI (USA).
Charts make it easier to understand the modelling results and are suitable for professional use.
Support a huge number of international and national generic and brand drug names, to make sure you can find information about medicine no matter who is the supplier/manufacturer of the drug or country of origin.
Mobile apps coming soon!

Benefits

Why do you need PK-Works?

For personal use:

Have a solution when you or your relatives miss medicine intake
Make your life more safe and protect from drugs overdose or underdose

For professional use:

Have a solution when your patients miss medicine intake, give correct advices
Protect patients from drugs overdose or underdose
Eliminate medical errors and negative side-effects

FAQ

General questions

What is the generic and brand drug names?

Each medicine has an approved name called the generic name. A group of medicines that have similar actions often have similar-sounding generic names. For example, phenoxymethylpenicillin, ampicillin, amoxicillin and flucloxacillinare in one group of antibiotics. Many medicines also have one or more brand (trade) names. This is chosen by the company that makes it. Several companies may make the same generic medicine, each with their own brand name. The name is often chosen to be memorable for advertising, or to be easier to say or spell than the generic name. For example, paracetamol is a generic name. There are several companies that make this with brand names such as Panado®, Calpol®, etc.

How does PK-Works work?

The PK-Works gives results based on our "know-how" algorithms of cross-databases information processing, so that we give precise and most complete information about drugs and their dosage.

Is PK-Works reliable?

The PK-Works is a reliable and trustworthy tool because it uses transparent safe processing algorithms and up-to-date information from world-wide drugs databases (AHFS, Stockley, MARTINDALE, USP-DI, F&C, etc.). The PK-Works has access to more drugs databases than any other tool on the market. More scientific information available at wiki area.

Can missing medicine intake be really dangerous?

Yes, absolutely. If you miss drugs intake you have underdose of the active ingredients in your body that obviously may lead to fatal results. When you increase drugs dosage to compensate that, you may accidentally overdose yourself that leads to negative and fatal results, too. That's why precise dosage is important. PK-Works helps you to calculate the right dosage.

Usability questions

Can I use PK-Works on my smartphone?

Currently PK-Works is available for Windows only. We're planning to make smartphone apps in the near future, too.

Do you have a trial or demo access to PK-Works?

Generally, we do not give a trial access. You may get a complete information about our product using screenshots, demo videos, texts, presentations and information at the wiki area. Our managers are pleased to make live presentations for you, consult and answer all your questions. Please, fill in the contact form and we will assign a personal manager for you.

Pricing and license questions

Does the PK-Works functionality depend on pricing plan?

No, the PK-Works provides the complete full functionality no matter what pricing plan you use. The difference between the pricing plans is only in the support features.

Can I use the PK-Works for my work?

Yes, you can. The PK-Works gives reliable results and is safe to use at your professional activities. However, you need to apply for the professional license. Besides, your company may apply for enterprise license that is more suitable for organizations.

Can I apply for personal license?

You can apply for the license if you're going to use the product as individual for personal (or family) use. You need professional license if you work as a doctor, nurse or in medical or healthcare company (clinic, hospital, drug store, etc.) or you plan to use it at your work or business (e.g. consulting company, law company, etc.).

Do you have any discounts?

Sometimes we make discounts, e.g. for Christmas or Black Friday, but it's not a general rule and may vary. We have flexible pricing plans that already include price reduction in higher plans. We have special offers for our existing clients for subscription renewals; please contact your personal manager for more information.

Reviews & feedback

Coming soon.

Software & hardware requirements

The PK-Works is distributed as Windows application. System requirements:

Windows XP, Vista, 7, 8, 8.1
1 Gb RAM
200 Mb HDD free space

Clients

Among our clients that use the DDI-Explorer are:

Ministry of Healthcare of Russian Federation (pre-order)

Support

We provide support services for our clients according to their pricing plans. The support is available via ticket system (coming soon), online chat (coming soon), support form and phone via call-center (coming soon).

Pricing and licenses

Currently the product is at final testing stage. Please, fill this form for pre-order to be the first who will gain access to the PK-Works. You will get special pricing and offers when the product goes live. We will assign personal manager for you who will inform you about the development details and help you pre-order/buy the product.