PK-Works

Coming soon! Pre-order available!

Overview

PK-Works is applied pharmacokinetic (PK) software that has been developed to cater for a wide range of needs for scholars and clinical practitioners in the domain of PKs. It has emerged as full-fledged system addressing basic PK situations as well as those that has neither been adequately dealt with in the PK literature nor by any other similar application software. These include the PKs of intermittent infusion, missed doses, PK of sustained release dosage form (SRDFs), targeting of drugs plasma ranges and individualization of dosing regimen with particular emphasis on kidney failure and hepatic dysfunction.

Unlike any other software, PK-Works has been supplemented by an extensive PK database covering more than 1,450 drugs substances and 38,000 brand products that are in use in the Russian Federation, European Union, Japan, the United States and Canada.

The compilation of the PK metrics of generic drugs was based on information supplied by major drug information databases including the American Hospital Formulary Service, Martindale Extra Pharmacopeia, LexiComp, and the USP-DI.

Since the PK profiles for all generics is not always available, user are informed of such instances and are requested to use reliable PK metrics for further processing of their drugs of interest. Such limitation in system is strictly related to the availability of these metrics in the scientific literature and will be subject to continual resolution in the future editions of the system.


Interactive PK Modelling

1. Drug selection

User may select the drug of interest from PK-Works database that contains PK information for all drug molecules available in the USA and Canada (about 1,450 drugs). It also contains names of about 38,000 branded drug products. Clicking on the database button (marked with RED) will cause the display of the drug selection dialogue box marked with the GREEN border line.

2. Default Profile

Once user has selected the drug of interest, the system displays its oral single dose as a default profile.

3. A single dose IV bolus plasma profile

A single dose IV bolus plasma profile could be readily simulated if selected by the user.

4. Drug Selection Wizard

In some instances, information pertaining to the PK metrics for some drugs may not be complete. Hence, users are required to enter values for such parameters (marked with RED) as shown hereunder.

5. Simulation Parameters

User may alter any of the simulation parameters (e.g. t|0.5). The system will display the new profile caused by such alteration in RED. If user accepts the new output, simulation will proceed with the new profile.

6. Multiple Dosing

Multiple dosing: could be easily simulated by defining the number of administered doses.

7. Likely Plasma Levels

Likely plasma levels: if variability, expressed as StDev, associated with PK metrics for the elimination or absorption rate constants is provided by the user, the system will display the likely plasma levels.

8. Dose Loading

For drugs with relative long t|0.5, a loading dose may be estimated by the system. Such a dose will produce steady state (SS) plasma levels as shown.

Wiki

More information about the concept of PK-Works, scientific results and explanations, statistical data and presentations available at wiki area.


Videos

Screencasts of the product, coming soon.


Features


Benefits

Why do you need PK-Works?

For personal use:

For professional use:


FAQ

General questions

What is the generic and brand drug names?

How does PK-Works work?

Is PK-Works reliable?

Can missing medicine intake be really dangerous?

Usability questions

Can I use PK-Works on my smartphone?

Do you have a trial or demo access to PK-Works?

Pricing and license questions

Does the PK-Works functionality depend on pricing plan?

Can I use the PK-Works for my work?

Can I apply for personal license?

Do you have any discounts?


Reviews & feedback

Coming soon.


Software & hardware requirements

The PK-Works is distributed as Windows application. System requirements:


Clients

Among our clients that use the DDI-Explorer are:


Support

We provide support services for our clients according to their pricing plans. The support is available via ticket system (coming soon), online chat (coming soon), support form and phone via call-center (coming soon).


Pricing and licenses

Currently the product is at final testing stage. Please, fill this form for pre-order to be the first who will gain access to the PK-Works. You will get special pricing and offers when the product goes live. We will assign personal manager for you who will inform you about the development details and help you pre-order/buy the product.

Please, provide your full name, so we can contact you if required
Please, select what licensing type you're interested in
Please, specify your contact phone in international format, e.g. +7 (843) 233-30-03
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